Beta
ManageChatDiscover
1450

Recovery Role of Genistein in Modulating the Alterations in Some Haematological Parameters and Hepatic Antioxidant Enzymes in Gamma Irradiated Mice

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

 GENISTEIN; 4',5,7-trihydroxy-isoflavone (C15H10O5) is an antioxidant nutrient, generally considered as a protective agent. The objective of this work is to study the radio recovery role of genistein in mitigating γ-rays induced injury to the liver and alterations in some haematological parameters of adult male mice. Genistein (150 mg/ kg body wt) was administrated to mice, once daily for 7 consecutive days before whole-body (4.5Gy) γ-rays-exposure then continued for 7 days after exposure.. The results showed that genistein significantly elevated liver catalase (CAT) and glutathione peroxidase (GPx) enzyme activities and decreased the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity. Genistein treatment also, accelerated the recovery of circulating white blood cells (WBCs) and reticulocytes (RETs) counts throughout the experimental time. On the other hand, genistein failed in recovering the red blood cells (RBCs) count. Conclusion: Genistein has significant radio recovery task in γ-irradiated mice.

DOI

10.21608/ejrsa.2011.1450

Keywords

genistein, oxidative-damage, radio recovery, γ-rays

Volume

24

Article Issue

1

Related Issue

316

Issue Date

2011-06-01

Receive Date

2011-04-14

Publish Date

2011-06-30

Page Start

1

Page End

13

Print ISSN

1110-0303

Online ISSN

2314-8527

Article File

EJRSA_Volume 24_Issue 1_Pages 1-13.pdf

PDF . 410.7kB

Link

https://ejrsa.journals.ekb.eg/article_1450.html

Detail API

https://ejrsa.journals.ekb.eg/service?article_code=1450

Order

1

Type

Original Article

Type Code

136

Publication Type

Journal

Publication Title

Egyptian Journal of Radiation Sciences and Applications

Publication Link

https://ejrsa.journals.ekb.eg/

MainTitle

Recovery Role of Genistein in Modulating the Alterations in Some Haematological Parameters and Hepatic Antioxidant Enzymes in Gamma Irradiated Mice

Details

Type

Article

Created At

22 Jan 2023