Introduction: It's well known that exposure to polycyclic aromatic hydrocarbons (PAHs) increases
the risk of cancer; however less is known about their adverse effects on male reproductive health. Aim of work: To assess the effects of occupational exposure to PAHs on male reproductive health in a company for coke production. Materials and methods: A cross sectional comparative study was performed on an exposed group of coal tar workers (No=45) and a matched control group (No=45). Personal interview with specially designed questionnaire and standardized self-completed questionnaire was done to assess the erectile dysfunction. Urinary 1-hydroxypyrene (1-OH Pyrene) and serum malondialdehyde (MDA) in addition to reproductive hormones and semen analysis were assessed. Results: The study revealed a statistically significant increase in the level of 1-OHpyrene,
MDA and estradiol ratio among the exposed group with Mean ±SD 8.42±3.61, 11.95±7.29, 7.89±3.45 vs 3.14±3.51, 2.44±1.61, 6.59±2.21 respectively among the controls with p < 0.05. As for reproductive hormones, no statistical significant differences were found between both groups. Erectile dysfunction score showed significant prevalence of moderate (28.9%) and severe (26.7%) grades of erectile dysfunction among the exposed group vs 11.1% and 8.9% respectively among the control (p<0.05). By doing Liner regression analysis, it was found that Testosterone and Estradiol ratio were the predictors for erectile dysfunction score (β=0.96 and 0.86 respectively) (p<0.05).
Concerning semen analysis, there was a statistically significant decrease in the seminal fluid volume, semen concentration and sperm motility (grade B) with increase of pus cells among exposed
group compared to the control group (p<0.05) while no significant difference for other semen parameter. A significant positive correlation was found between 1-OHpyrene and MDA (r =0.63, p<0.001), while no significant correlation was found between 1-OHpyrene, MDA on one side and 
reproductive hormones on the other side (p>0.05). Conclusion and recommendations: The adverse
health effect on the male reproductive system in the current study might be one of the hazards that can be attributed to occupational exposure to PAHs in coal tar workers. Regular wearing of good quality personal protective equipment, especially masks and gloves is highly recommended to decrease
exposure to PAH in addition to screening with urinary 1-OH pyrene and serum MDA levels.