Introduction: Exposure to chromium (Cr) and nickel (Ni) is prevalent at workplace. Although they are toxic,
human studies on their effect on the reproductive system are few and contradictory. Aim of work: To evaluate
the association of male reproductive hormone levels with the concentrations of blood chromium and nickel
among electroplaters in a factory for metallic industries in Egypt. Materials and methods: A cross sectional
comparative study was conducted on 48 electroplating workers and 48 non-occupationally exposed subjects
used as controls. Personal interview with specially designed questionnaire were fulfilled. Blood nickel and
chromium concentrations were determined and the reproductive hormones levels [follicle stimulating hormone
(FSH), luteinizing hormone (LH), testosterone and inhibin] were assayed for all participants. Results: The
study showed a statistically significant high levels of the mean values of blood Cr and Ni among electroplating
workers compared to the control group (1.2±0.93 and 1.3±1.02 μg/L vs 0.4±0.1 and 0.39±0.2 μg/L respectively;
p<0.001). Also, a statistically significant high levels of FSH and LH were detected among exposed workers
(5.19±2.08 mIU/L and 6.85± 2.67 IU/L respectively) compared to controls (1.95±0.7 mIU/L and 3.97± 0.85
IU/L respectively) with low levels of testosterone and inhibin. Significant positive correlations (p<0.05)
were found between FSH level and heavy metals (Cr and Ni) levels (r=0.28 and r=0.63; p=0.05 and p<0.002
respectively). Conversely, significantly negative correlations were detected as regards testosterone level (r=-
.323 for chromium and r=-.571 for nickel; p<0.05 for each). Blood nickel was found to be a significant predictor
for FSH and testosterone level, and smoking index was predictor for all measured reproductive hormones
among exposed electroplaters. Conclusion: Exposure to high levels of Cr and Ni might affect reproductive
hormones levels among male electroplating workers. Regular wearing of good quality's personal protective
equipment, especially masks and gloves, to decrease exposure to electroplating fumes, is highly recommended.