s one of the most vital factors that define efficiency and productivity of human resources. In Egypt, nurses are the backbone of the health care system. However, they are not well appreciated in most institutions. Nurses' job satisfaction is a multidimensional occurrence affected by many variables. Aim of work: to assess the level of job satisfaction and its associated socio-demographic and workplace factors among nurses working in Mansoura University Hospital (MUH). Materials and Methods: A cross-sectional study was conducted among Mansoura University Hospital nurses during the period from 1March to 31May 2017. The data was collected using self-administered questionnaire formed of three parts: Socio-demographic characteristics, Work characteristics and McCloskey/Mueller Satisfaction Scale (MMSS) that having eight subscales to assess nurses' job satisfaction level. Results: A total of 346 nurses were included, yielding a response rate of 88.49%. The majority of our group expressed low job satisfaction (61.8 %). The significant independent predictors of low job satisfaction among nurses were in the following order: lack of communication with their colleagues (OR =4.18) and deprivation from supervisor support (OR =2.32). Conclusion: The present study indicated that nearly two thirds of Mansoura University Hospital nurses expressed low job satisfaction. Lack of colleagues-communication and supervisor support at work predicted the outcome variable. Achievement of high level of job satisfaction is recommended to provide high-quality health care system. With this information, staff nurses could improve their own satisfaction by cultivating their peer communication. In addition, changing attitude of nurse supervisor towards positive relation with staff nurses is crucial to increase job satisfaction.