stress reaction syndrome caused by chronic exposure to job-related stressors; and characterized by Emotional Exhaustions (EE), Depersonalization (DP), and a low sense of Personal Accomplishment (PA).Health-care providers (HCPs) are particularly vulnerable and prone to burnout syndrome (BOS). Aim of work: To estimate frequency and recognize risk indicators for BOS among HCPs in Minia city. Materials and methods: A total of 280 hospital workers from three different hospitals in Minia city completed a self-administered questionnaire that was used to measure BOS. Data was collected using Maslach Burnout Inventory (MBI). Results: Health care providers reported high levels of EE (61.8%), high levels of DP (52.5%) and low levels of PA (45.7%). Surgical department's HCPs showed the highest score of burnout in EE level, however those in emergency department recorded the highest level in both (DP) and (PA). The 3 subscales were high among those with longer duration at work. Using logistic regression, the most significant predictors of EE were found to be gender followed by years of working, and smoking status. Factors associated with DP were years of working followed by age, hours of working shift, and with PA were age followed by sleeping time, and gender. Conclusion: Health care providers are highly vulnerable to each of the dimensions of Burnout syndrome – namely emotional exhaustion, depersonalization, and personal accomplishment- in the hospital work. Decreasing BOS by incorporation of mindfulness and teamwork into practice, decrease stress from electronic health records, promote physician control of the work environment, and to find balance in life.