Introduction: Occupational health and safety is an important component of national development. Occupational health and safety is relevant to all branches of industry, business and commerce including traditional industries, information technology companies. Safety climate can be regarded as the surface features or indicator of safety culture emerged from workforce's attitudes and perceptions. Organizational climate is conceived to be a critical determinant of individual behavior in organizations. Aim of work: The current study was designed to perform a multi-level comparative analysis on employee's perception for safety climate dimensions in petroleum and petrochemical of three industrial sectors; multinational, investment and public, in Egypt. Materials and methods: Data were collected utilizing a modified-NOSACQ-50 questionnaire for the seven safety domains including 66 questions, constructing safety climate dimensions which are; management commitment, safety training, workers' involvement, safety communication and feedback, safety rules and procedures, and safety promotion policies, as well as self-reported safety behavior of employees. The questionnaire was distributed to 6 petroleum companies (two companies of each sector) targeting all employees. Results: Analysis of data revealed significant differences in employee's perception on safety management practices among the three petroleum sectors especially in worker involvement domain and safety rules and procedures applied in those companies. Conclusion: Workers' involvement was the main extracted factor for proper safety climate establishment within an organization and should be taken into consideration for decision making in safety matters. The research provides useful information for project managers and safety practitioners who desire to improve safety performance within an organization.