Introduction: Work-related musculoskeletal disorders (WMSDs) among dentists are prevalent complaints. The symptoms might impair work capacity and the future possibility to stay in the profession. Aim of work: to assess the prevalence and distribution of work related musculoskeletal disorders (WMSDs) among dentists working in Sharkia governmental hospitals and to determine the risk factors among them. Materials and methods: A cross-sectional study was conducted among (123) dentists. A self-administered questionnaire that involved information about: socio-demographic and work-related data, a version of Standard Nordic MSD questionnaire, and a version of Demand/Control model questionnaire from Karasek. Results: The overall prevalence of MSD was (66.7%). Low-back pain was the most prevalent musculoskeletal complaint that reported by (56.9%) of the subjects, followed by wrist, neck and shoulders complaints (50.4%, 47.2% and 42.3% respectively). Age more than forty years, duration of work more than ten years, use of vibrating tools and low job control were the most significant predictors of work-related musculoskeletal disorders among the studied dentists with (OR= 2.70, 2.72, 5.32 and 4.85 respectively).Conclusion: WMSDs are significant problems among dental practitioners. Repetitive tasks, using of vibrating tools, bad working habits, and uncomfortable posture contribute to musculoskeletal disorders, loss of production and stress. Educational dental ergonomics program should be introduced as a separate course during undergraduate practice.