Introduction: inspiratory muscle training (IMT) improves exercise capacity and ventilatory responses to exercise in CHF patients with inspiratory muscle weakness (IMW). Aim of Work: to investigate the effect of inspiratory muscle training (IMT) with comprehensive cardiac rehabilitation (CR) program (aerobic and resisted exercise training) on ventilatory changes in chronic heart failure patients. Materials and Methods: Forty eligible male patients with chronic heart failure secondary to ischemic heart disease but only thirty of them completed the study. Their ages ranged from 50-60 years old .They were randomly assigned to 6 months of aerobic exercise, resisted exercise plus IMT (n=15) or to aerobic exercise plus resisted exercise only (n=15), Before and after intervention, the following measures were obtained: maximal inspiratory muscle pressure (PImax), ventilatory equivalent of CO2 at anaerobic threshold of cardiopulmonary exercise testing. Result: Compared aerobic exercise (AE) + IMT to AE resulted in additional significant difference in EqCO2 (25.43% vs 16.77%) and in PImax (14.81%. vs 34.94 %.). Conclusion: This study demonstrates that the addition of IMT to AE results in improvement in ventilator responses to exercise in selected patients with CHF and IMW