Introduction: Patients with fatty liver disease complain from fatigue and have decrease quality of life. Life change behaviors as diet and exercise are the most important recommendation from therapists. However little is known about type and intensity of exercise which is beneficial in fatty liver diseases management. Aim of work: To assess the effect of high intensity interval training compared to resistance training on quality of life and six minute walk distance in fatty liver disease patients. Materials and Methods: Twenty one female patients with fatty liver disease were assigned to supervise high intensity interval training (HIIT) or resistance training (RT) for eight weeks, paired t test was used for statistical comparison. Results: The results showed that both types of exercise improved quality of life and six minute walk distance significantly, but HIIT was superior to RT in improving Body Mass Index (BMI), 6 minutes walk distance (6MWD) and Chronic liver disease questionnaire (CLDQ). Conclusion: So, it can be concluded that high intensity interval training was more appropriate than resisted exercise training in improving quality of life and six minute walk distance in fatty liver disease patients.