Introduction: Pesticides, pesticide products and related chemicals have been found to have a wide range of health effects. Many farmers' activities pose serious risks of pesticide exposure, such as land preparation for cultivation, storing, mixing, preparing and spraying of pesticide, loading and cleaning of spraying equipment. Farmers' knowledge and perception about pesticide risks play an important role in determining the use of pesticides protective device. Aim of Work: (1) To assess knowledge of farmers, their families toward pesticide use and pesticide hazards in Wadi El Mullak village (2) To assess safe pesticide use behavior (3) To evaluate the effect of health education program on their knowledge, attitude toward pesticides exposure. Materials and Methods: This study was conducted through two phases (a cross- sectional study, and an intervention educational program) among farmers living in EL-Mullak village for at least 3 months from the time of interview, participants of the cross sectional phase were (n=202), were satisfying the inclusion criteria. An interviewer questionnaire was filled before and after the health education intervention program, a checklist was also utilized to determine the actual practices of the respondents in the field before and after the intervention. Results: (1) there are a significant relation between farmers' educational level and their level of knowledge (2) there is a statistically highly significant effect of health education of the intervention program on farmers' knowledge of safety behaviors 
associated with pesticide use (3) there is significant relation between receiving previous training on pesticides issues and decreased appearance of symptoms. Conclusion and Recommendations: This study concludes that health education and proper training are effective forms of intervention in improving the knowledge, attitude and practices of farmers on the use of pesticide.