Introduction: Immunoglobulin A (IgA) is the main class of antibodies present in the body secreted fluids such as saliva, tears or mucus from the intestines. The meaning of IgA in serum is still unclear. It was postulated that this immunoglobulin performs a complementary role in the neutralization of the pathogens, which defeated the mucosal barrier, as well as macrophage activation, and removal of immune complexes formed with the participation of this isotype. Aim of Work: To investigate the effects of resistance exercise on Cortisol, Immunoglobulin A (IgA), and Creatine kinase (CK) responses of male students. Materials and Methods: Ten subjects (mean age 21.0 ± 1.5 years) completed two trail, aerobic Treadmill exercises (60% VO2max; 45-min) and resistance (80% 1RM; 45-min) exercise concurrently; each subject was his own control. Blood samples were collected pre-exercise, post-exercise, and 3 hours after exercise. One-way ANOVA with repeated measure and LSD post-hoc tests were used to evaluate changes in Cortisol, CK, and IgA during baseline and exercise periods. Results: During baseline, there were no differences between exercise day (ED) values and those obtained at rest day (RD) for Cortisol, CK, and IgA. After exercise, Cortisol concentration in ED was significantly higher than RD (p<0.05); however, changes in IgA and CK responses were not significant. Conclusions: This type of consecutive exercise didn't increase susceptibility to upper respiratory tract infection and muscle damage. Therefore, it can be useful for the preparation phase of training for athletes.