Nowadays a special attention is focused on a variety of Occupational and Environmental exposures and their impact on male and female reproductive health. Such exposures may negatively affect the reproductive process causing reduced fertility and adverse pregnancy outcomes in the exposed population.This article aims at evaluating the impact of Occupational and Environmental exposures to several widespread toxicants on reproductive health by reviewing most recent published literature. The results from the presented studies suggest that there are strong and rather consistent indications that the reproductive system is particularly vulnerable to insult from exposure to widespread occupational and environmental agents. Considering the possible health effects, more epidemiologic data is needed.