Background: Work ability is defined as the ability of the worker to perform his job,taking into consideration the work demands, the worker's health status and his mental resources. Many factors may influence the work ability. Aim of work : to determine the influence of individual, socio-demographic and work-related characteristics on the work ability of office workers and to determine the relative contribution of different factors to the level of work ability. Materials and Methods: A cross sectional study was conducted at the administrative departments of Ain Shams University. A total of
892 office workers completed a predesigned self-administered questionnaire including data about socio-demographic, lifestyle and work-related characteristics in addition to Work Ability Index. Measurements of height and weight were also performed. Results: Using multiple linear regression analysis; age, Body Mass Index and performing dual work were found to be negatively influencing the work ability of male workers, while practicing physical exercise and eating balanced diet were positively influencing it (R²= 0.34). Marital status, number of children and Body Mass Index were found to be negatively influencing the work ability of female workers, while practicing physical exercise, adequate sleep and eating balanced diet were positively influencing it (R²= 0.26). Conclusion: Some individual, lifestyle and work-related factors have asignificant influence on the work ability among office workers.