The liver is the target organ of many occupational and environmental agents and plays a central role in their etoxification as well as the elimination of many toxic chemicals and/or their metabolites . A previous study was done three years ago on 389 subjects in a chemical factory for pesticide formulators, it revealed that there was a significant seroprevalence of
HCV & HBV among studied workers as well as significant elevation of ALT enzymes among both seropositive and seronegative HCV & HBV . This work was done on 150 selected workers from a previous study three years ago in a chemical factory formulating pesticides. All selected subjects were assessed by clinical examination regarding mplications and risk factors of hepatitis, laboratory investigations and abdominal ultrasonography.We concluded from this study that there is an increase in the curve of progression of chronic liver disease among studied subjects on follow up and this may be due to presence of another contributing factor which is chronic exposure to pesticides.