THE MEDICINAL plants have vital sources of natural antimicrobial substances for human health avoiding side effects precipitated by using synthetic chemical. The decreasing effectiveness of traditional antibiotics towards multi drug resistant microorganism is a global public health. It was found that the mixtures between different plant extract and commercial antibiotics increased the effectiveness of antibiotics multi drug resistant bacteria. The combinations between different plant extract and commercial antibiotics increased the effectiveness of antibiotics against multi drug resistant strains. Extracts of Moringa oleifera leaves showed remarkable antimicrobial activity against the growth of the gram positive and negative bacteria drug resistant clinical strains (Escherichia coli ATCC 10536, Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus ATCC 29737 and Staph epidermidis ATCC 12228, Bacillus pumilis ATCC 14884, Micrococcus luteus ATCC 10240, Bordetella sp, Bacillus subtilis and Klebsiella sp . Antimicrobial activity of methanol extract of Moringa oleifera leaves (MML) using well diffusion method was higher (30mm inhibition zone) than ethanolic and aqueous extract. The minimum inhibition concentration (MIC) of the selected pathogenic bacteria ranged between 23 -800μg/ml. The interactions between different extract of Moringa oleifera leaves and different antibiotic groups of Ampicillin (Am10), Amoxicillin (AMC30), Amikacin (AK30), Gentamycin (CN10), Tetracycline (TE30), Erythromycin (E15), Bacitracin (B10) were conducted using agar diffusion method against the selected pathogenic bacteria. Methanol extract of Moringa oleifera leaves could be used as a source for resistance-modifying agents against infectious multi-drug resistant bacteria.