Urinogenital infections proved to be one of the most common diseases which mankind can face nowadays. Both men and women can be infected by the urogenital pathogens but the last are considered more susceptible to these injuries due to their physiological nature. The emergence of multi-drug resistance phenomenon made the treatment with such antibiotics is useless. Urinary tract infection (UTI) caused by bacteria is considered one of the most frequent injuries infecting both male and female. The development of multi-drug resistance phenomenon in bacteria leads to the necessity of finding an alternative remedy. Probiotics are suggested as a suitable and appropriate solution. In this study, CFS of Lactobacillus plantarum LPS10 is examined for its inhibitory effect against clinical urogenital bacterial strains and Candida albicans isolated from UTI infections. CFS obtained from this probiotic showed a promising antibacterial and anticandidial results. L. plantarum LPS10 possessed the capability to be used as a probiotic against clinical bacteria isolated from urogenital infections.