Background: Aspirin induced gastric mucosal injury, which leads to gastric ulcer. Adipose Derived Mesenchymal Stem Cells (ADMSC) can be used for treatment of gastric ulcer as they can differentiate into many cell types. Omeprazole is used for treatment of gastric acid-related disorders.
The Aim of the Work: Was to compare between the therapeutic role of ADSMC and omeprazole in treatment of gastric ulcer
Material and Methods: Forty male albino rats were divided into four equal groups: 1-Control group. 2-Aspirin group in which rats were fasted for 24 hours, then given acetylsalicylic acid (200 mg/kg) once orally for induction of ulcer. 3-ADMSC-treated group in which rats were treated by (3 × 10⁶) ADMSCs/ rat once by intravenous injection four hours after induction of ulcer. 4-Omeprazole-treated group in which rats were treated by omeprazole suspension (20 mg/kg) orally, four hours after induction of ulcer, and for five days. Gastric juice volume and acidity, length of gastric ulcer, and histopathological and immunohistochemical changes of the stomach were all evaluated.
Results: Aspirin induced erosion and loss of architecture of gastric mucosal epithelium, ADMSC treatment reduced the length of gastric ulcer, ameliorate histopathological changes and reduced the PCNA-LI also the omeprazole treatment promoted healing of the gastric ulcer induced by aspirin but the therapeutic role of ADMSC was significantly lower in ulcer index and PCNA-LI and better in PAS reaction and histopathological healing of gastric ulcer than the therapeutic role of omeprazole.
Conclusion: The therapeutic role of ADMSC was found to be superior to omeprazole in treatment of gastric ulcer.