78157

Topical Olive Oil with Downregulation of Stress Factors Protects Mice Skin from Precarious 600 MHz Electromagnetic Radiation

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

-

Abstract

Background: Recently, studies are concerned with electromagnetic radiation (EMR) as one of the most physical factors to which a biological body and hence skin are exposed. Research also demonstrates that topical olive oil can prevent skin damage.
Aim of work: This study aimed to examine the histological, biochemical, and immunohistochemical changes in the skin tissue of adult mice after exposure to 3600 MHz (for 2 weeks) electromagnetic waves as well as the protective role of topical olive oil on mice skin For this,
Materials and Methods: Thirty adult mice were categorized equally into six groups control; olive oil; EMR-exposed: mice exposed to 3600 MHz for 2 weeks; Pre, Post-EMR groups: mice painted with topical olive oil pre and post-exposure respectively for 2 weeks; recovery group: mice left 2 weeks after exposure without any treatment. Histopathological examination and biochemical analysis were performed.
Results: Mice exposed to EMR showed several histological changes as increased thickness and discontinuation of the epidermis, flat epidermal-dermal junction, dermal cell atypia, and hair follicle degeneration, disorganized and fragmented collagen and elastic fibers. Furthermore, reduced catalase activity, and increased malondialdehyde (MDA) content and inflammatory cytokines, Tumor necrosis factor (TNF)-α and interleukin (IL)-6. Also, up-regulation of tumor protein (P) 53, caspase 3, and HSP (heat shock proteins)-70 were observed in the skin of mice. These changes were improved by using topical olive oil that is more pronounced in Pre-EMR than Post-EMR with partial insensible effect in the recovery group.
Conclusion: The present work showed that olive oil protected mice's skin against EMR, especially when used before exposure through amelioration of oxidative, inflammatory, and heat shock stress factors. The absence of exposure leads to a partial return to the control state for further studies.

DOI

10.21608/ejh.2020.25095.1259

Keywords

Electromagnetic radiation, Immunohistochemistry, olive oil, skin, Stress

Authors

First Name

enas

Last Name

soliman

MiddleName

fathy

Affiliation

anatomy and embryology, faculty of medicine, menufia university, shebin elkom, egypt

Email

dr.enas_soliman@yahoo.com

City

tanta

Orcid

0000-0002-5315-5853

First Name

hanaa

Last Name

nooh

MiddleName

zakaria

Affiliation

anatomy and embryology department, faculty of medicine, menufia university. shebin elkom, egypt

Email

drhanaanooh@gmail.com

City

shebin elkom

Orcid

0000-0001-9464-4971

First Name

wael

Last Name

elkholy

MiddleName

badr

Affiliation

anatomy and embryology department, faculty of medicine, menufia university, shebin elkom, egypt

Email

wael_elkholy71@yahoo.com

City

shebin elkom

Orcid

0000-0002-5973-1356

First Name

rasha

Last Name

radwan

MiddleName

radwan

Affiliation

Drug Radiation Research Department, National Center for Radiation Research & Technology, Atomic Energy Authority, nasr city, egypt

Email

rasha_radwan33@yahoo.com

City

nasr city

Orcid

0000-0001-7344-2123

First Name

marwa

Last Name

Al-Gholam

MiddleName

Abdel-Samad

Affiliation

anatomy and embryology, faculty of medicine, menufia university, shebin elkom, egypt

Email

marwaelgholam@yahoo.com

City

shebin elkom

Orcid

0000-0002-1948-184x

Volume

44

Article Issue

2

Related Issue

27775

Issue Date

2021-06-01

Receive Date

2020-03-03

Publish Date

2021-06-01

Page Start

563

Page End

573

Print ISSN

1110-0559

Online ISSN

2090-2417

Link

https://ejh.journals.ekb.eg/article_78157.html

Detail API

https://ejh.journals.ekb.eg/service?article_code=78157

Order

20

Type

Original Article

Type Code

119

Publication Type

Journal

Publication Title

Egyptian Journal of Histology

Publication Link

https://ejh.journals.ekb.eg/

MainTitle

Topical Olive Oil with Downregulation of Stress Factors Protects Mice Skin from Precarious 600 MHz Electromagnetic Radiation

Details

Type

Article

Created At

22 Jan 2023