Background: Methylprednisolone causes a delay in dental extraction wound healing. There are finite data for the effect of Aloe Vera gel and silver nanoparticles gel on tooth socket healing in methylprednisolone treated Albino rats.
Purpose: To evaluate the topical effect of using Aloe Vera gel versus silver nanoparticles gel on socket healing in methylprednisolone treated Albino rats.
Materials and Methods: Adult male Albino rats were divided into three groups. Group I (control group); Subgroup A and Subgroup B: received intramuscular injection of sterile normal saline and methylprednisolone acetate (0.2 mg/kg, 3 times/week for 5 weeks) respectively. After this period, lower right first molars were extracted. Group II and Group III were as group IB while, the sockets were filled with 92% Aloe Vera and silver nanoparticles gel respectively. Rats were sacrificed at day 7 and day 14. Rats' sockets were processed for histological and scanning electron microscopic examination.
Results: Group IB showed a delay in socket healing. Group II showed the socket was filled with osteoid matrix at day 7. Then the socket was nearly filled with thick intercommunicating lamellar bone trabeculae with wide bone marrow spaces at day 14. Surprisingly, Group III revealed thin intercommunicating woven bone spicules at day 7. At day 14, the socket became nearly obliterated with thick intercommunicating bone trabeculae with formation of numerous primary osteons with small bone marrow spaces.
Conclusion: MP had a marked osteoporotic effect on rat mandible and delayed the socket healing process. Aloe Vera gel and AgNps gel improved the socket healing in MP treated Albino rats.