92458

Ameliorative Effects of Panax Ginseng on Lung of Lambada Cyhalotherin-intoxicated Rats

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Last updated: 01 Jan 2025

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Abstract

Introduction: Lambada-cyhalotherin (LCT) caused severe oxidative damage in liver, lung and testis.
Aim of the Study: The objective of this research was to evaluate the ameliorative activity and underlying techniques of pure Panax ginseng (G) using rat model of LCT-induced lung damage.
Materials and Methods: 36 male adult laboratory rats Rattus norvegicus domestica in weights around 135±10 g were separated into 6 experimental groups: 1st control group. 2nd and 3th groups were G groups (100 and 200 mg G/kg b. wt.) LCT group was given by oral gavage LCT (61.2 mg /kg b. wt.) that is equivalent to 1/10 of LD50. The 5th and 6th groups were co-treated with two doses of G.
Results: LCT significantly decreased superoxide dismutase (SOD), catalase (CAT) and total thiol (T. thiol) and increased lipid peroxidation (LPO). mRNA and protein expression levels of p53 gene (apoptotic gene) were increased, whereas, Bcl-2 gene (anti-apoptotic gene) mRNA and protein expression levels were decreased in LCT-treated animals. Also, light microscopic and ultrastructure studies for lung tissues of LCT-treated animals showed marked hyperplasia of dilated bronchioles wall, RBCs extravasation in bronchiolium lumen and mononuclear leukocytic infiltration in parenchyma. Additionally, blood vessels congested with thickened walls, alveoli appeared collapsed with compensatory expansion of adjacent alveoli divided by thickened inter-alveolar septa, besides to damage in type 1 and type 2 pneumocytes. G co-treatment attenuated oxidative stress biomarkers. Both tested doses of G significantly decreased p53 and elevate Bcl-2 mRNA and protein expression levels and revealed significant amelioration and restoration of normal histology and ultrastructure of lung.
Conclusion: In summary, G has exhibited ameliorative activity against oxidative stress induced by LCT in lung, apoptosis, histopathological and ultrastructural changes in albino rats.

DOI

10.21608/ejh.2020.30560.1293

Keywords

antioxidants enzyme activities, histopathology and ultrastructure of the lung, lambda-cyhalothrin, Panax ginseng

Authors

First Name

Karim

Last Name

Zaied

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

Email

karim_zaied9163@yahoo.com

City

-

Orcid

-

First Name

Hanaa

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

Email

marawanahmed@hotmail.com

City

-

Orcid

-

First Name

Sanaa

Last Name

Abd El-Twab

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt

Email

sabdeltwab@yahoo.com

City

-

Orcid

-

First Name

Manal

Last Name

Abdul-Hamid

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Beni-Suef University, Egypt

Email

medo_bio@yahoo.com

City

-

Orcid

0000-0002-0877-3097

Volume

44

Article Issue

1

Related Issue

25818

Issue Date

2021-03-01

Receive Date

2020-05-18

Publish Date

2021-03-01

Page Start

61

Page End

82

Print ISSN

1110-0559

Online ISSN

2090-2417

Link

https://ejh.journals.ekb.eg/article_92458.html

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https://ejh.journals.ekb.eg/service?article_code=92458

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5

Type

Original Article

Type Code

119

Publication Type

Journal

Publication Title

Egyptian Journal of Histology

Publication Link

https://ejh.journals.ekb.eg/

MainTitle

Ameliorative Effects of Panax Ginseng on Lung of Lambada Cyhalotherin-intoxicated Rats

Details

Type

Article

Created At

22 Jan 2023