The study was conducted at El-Kasasin Research Station belonging to Ismailia Governorate, during the 2019 and 2020 seasons on Salvia officinalis plants. The experiment design was split plots, the main plots were two levels of vermicompost 2, 4 m3, and control treatment, while the subplots were springing with some vitamins; C, B1, and mixture of vitamin C + B1, and the control treatment. Consequences revealed that there was a significant effect resulting from the use of vermicompost at a rate of 4 m3 on all vegetative growth characteristics and essential oil compared to untreated plants. Alternatively, there was a significant effect on the characteristics of plant growth including plant height (cm), the number of branches, fresh and dry weights per plant (g) and per feddan (tons) and oil production included oil percentage in leaves dry weight; oil content per plant (ml) and per feddan (L) resulted from spraying with a mixture of vitamin C + B1 compared to the other treatments and control plants. Also, a significant effect has resulted from the interaction between adding vermicompost and spraying with vitamins on all growth characteristics, essential oil, and essential oil compounds, where the treatment recorded 4 m3 vermicompost + spraying with the vitamins mixture C + B1 compared to the other treatments and untreated plants. The results showed that, treatment of 4 m3 vermicompost + the vitamins mixture C + B1 recorded the highest values in both thujone (57.102%) and camphor (13.657%), while the compound 1.8-cineole recorded 3.256%, camphene recorded 1.846% and caryophyllene recorded 4.160%.