MARRUBIUM VULGARE L (white horehound) is a perennial flowering species belongs to Labiatae (Lamiaceae). Marrubium genus is native to North Africa, Europe, and the Mediterranean basin. Worldwide, it represented by 30 species. In Egypt, there are two species only distributed in the northern coastal belt wherever calcareous or oolitic sand formation, especially in marginal lands and waste ground, the ruins of the old abandoned house and road sides. The main differences between the two species are life span (perennial and annual), number of calyx teeth (10 and 5) and the color of the corolla (white and pale pink) of M. vulgare and M. alysson, respectively. With the accelerated rate of climate change and urbanization and their destroyed effects on biodiversity loss and fragmentation of habitat. This study examines if some species could adapted to habitat disturbance. For this purposes we choose M. vulgare as a model species for habitat disturbance. Phenological aspects, distribution, density, size structure and reproductive efforts of M. vulgare were studied in four different locations in the western Mediterranean section. Locations are representing two different habitats: Road sides (wild habitats) and abandoned places (urban habitat). The study claimed that there are a significant difference between reproductive efforts, size index and density, whereas, no differences between the phenological aspects.