DROUGHT is one of a considerable environmental stresses limiting productivity of crops. This work was conducted to investigate the effect of foliar spray of plant leaf extract (Moringa olifera) to alleviate drought stress in Glycine maxplants (cv.Giza 111). Drought caused significant decreases in growth parameters (shoot and root length, fresh and dry weight of shoots and roots) and photosynthetic pigments (chlorophyll a, chlorophyll b, carotenoids and total pigments). In addition, it caused significant increasesi n non-enzymatic antioxidants (ascorbic acid, tocopherol and reduced glutathione), enzymatic antioxidants (glutathione reductase, superoxide dismutase and ascrobate peroxidase), oxidative damage (lipid peroxidation) and osmolyte compounds (proline, total soluble sugars and total phenols) in soybean plants. Moreover, foliar spray with Moringa leaf extract (MLE(30)) enhanced all the above parameters as compared with either the control plants and drought stressed plants. It appeared that MLE (30) was able to enhance the tolerance of the studied plant to drought stress.