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3778

Evaluation of Antifungal Activity of some Plant Extracts Against Causing Agents of Water-Related Fungal Keratitis

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Last updated: 01 Jan 2025

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Abstract

 HIGH levels of pollutants in the River Nile water caused severe alteration in the pollutant indicators such as temperature, pH, dissolved oxygen, chemical oxygen demand, ammonia and nitrate; in addition to the concentration of some heavy metals (e.g. lead, mercury and cadmium) which made water unsuitable for drinking, irrigation and aquatic life. Microbiological results indicated that Rosetta branch had subjected to sewage pollution with the common occurrence of Candida pelliculosa, Candida tropicalis, Trichosporon mucoides and Aspergiulls niger. The infectious mycotic keratitis among patients of the surrounding residential area was closely related to the identified yeasts and filamentous fungal isolates from water samples. Methanolic leaf extract of Melaleuca alternifolia tree showed a significant inhibition for the most common yeast and filamentous fungal causative agents, especially against Candida pelliculosa and Trichosporon mucoides, confirmed with ultra-structural cellular distortions, that were observed by transmission electron microscope (TEM). The minimum inhibitory concentrations (MIC) were also recorded. Melaleuca alternifolia leaf extract was analyzed by Fourier transformation Infra-red (FT-IR) spectroscopy and gas chromatography / mass spectrum (GC/MS).

DOI

10.21608/ejbo.2016.3778

Keywords

River Nile, Pollutant Indicators, Water-Related Infectious Diseases, Candida pelliculosa, Trichosporon mucoides, Melaleuca alternifolia

Volume

56

Article Issue

3

Related Issue

507

Issue Date

2016-09-01

Receive Date

2016-06-27

Publish Date

2016-09-30

Page Start

837

Page End

861

Print ISSN

0375-9237

Online ISSN

2357-0350

Article File

EJBO_Volume 56_Issue 3_Pages 837-861.pdf

PDF . 1.1MB

Link

https://ejbo.journals.ekb.eg/article_3778.html

Detail API

https://ejbo.journals.ekb.eg/service?article_code=3778

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18

Type

Original Article

Type Code

111

Publication Type

Journal

Publication Title

Egyptian Journal of Botany

Publication Link

https://ejbo.journals.ekb.eg/

MainTitle

Evaluation of Antifungal Activity of some Plant Extracts Against Causing Agents of Water-Related Fungal Keratitis

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Article

Created At

22 Jan 2023