IMPETIGO is one of the infectious superficial bacterial diseases and its
treatment with antimicrobial agents may cause serious problems. So, a
test of new microbial infection-fighting natural compounds is necessary. In
the present study, histological examinations of the experimental animals
revealed the effectiveness and safety of Chlorella vulgaris methanolic
extract ointment used in the treatment of impetigo, tinea corporis and
cutaneous candidiasis without any side effects on skin tissues. In addition,
examination of skin sections treated with C. Chlorella vulgaris extract
possessed no significant toxic effects. The skin appeared with normal
epidermis as the keratinized fibers of stratum corneum were regularly
arranged, appeared condensed without any disruption. The dermis
appeared normal with minimal inflammatory cellular to infiltrate with
the formation of hair follicles and sweat glands in comparison with a healthy
skin. According to the chemical analyses of Chlorella vulgaris, the
antimicrobial material was defined as a phenolic compound having the
following formula C14H17NO4 and the suggested structure could be 2- (1-
hydroxy-2- (4-hydroxyphenyl)-2- methoxyethyl - 4- oxopentane nitrile.