THE SEASONAL effects on the ecophysiological responses of Asph Asphodelus aestivus Brot. (A. microcarpus) were investigated. Changes in water content, degree of succulence, osmotic potential, photosynthetic pigments, carbohydrate fractions, mineral contents, total lipids, total phospholipids and activities of certain antioxidant enzymes were investigated in leaves and root tubers of the studied plant. Soil moisture content decreased generally during autumn season. Total chlorophyll,carotenoid,K⁺,Mg⁺², P⁺³and total carbohydrate contents, in leaves in early autumn, showed an increase however root tubers exhibited an increase in most ions such as K⁺, Na⁺, Ca⁺²,Cl^- and P⁺³. Asphodelus aestivus showed a specific defense strategy against ROS to achieve adaptation by increasing activities of specific enzymes such as superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), Polyphenol oxidase (PPO) and GR glutathione reductase (GR), in root tubers, SOD, GR and Glutathione peroxidase (GPX) in leaves. Asphodelus aestivus has developed different defense strategies against drought stress and completed a specific life form cycle, which might be considered as an intermediate stage between avoidance and tolerance to being well adapted against water stress.