SALINITY and wilt disease are of the most popular stress conditions that face crops specially rice, our study aims to evaluate the biochemical response of rice plants to wilt disease and salinity stress under silica ions and nanoparticles application. Rice plants grew under Fusarium infection (wilt disease) stress and irrigated with five different concentrations of NaCl in peat moss incorporated with sodium silicate solution and peat moss similarly supplemented with nano silica solution, the samples were collected for biochemical analysis in three stages (3, 6 and 9 days from treatment). The pigments, plasma membrane permeability, H2O2, lipid peroxidation, antioxidant enzymes and proline content were determined. The results showed that the silica ions caused improvement of the biochemical status of rice plants under the applied biotic and abiotic stress, while nano silica caused suppression of these criteria under the same biotic and abiotic stress condition.