Thalamus is a subcortical brain structure divided into smaller nuclei with specific functions that aid in neuronal signal transmission and regulation, it has been the subject of a lot of neurological studies and clinical therapies, traditional imaging modalities like T1 and T2-weighted imaging provide weak contrast in the thalamus. The thalamus has been demonstrated to be a promising target for Susceptibility-weighted image (SWI). SWI is a T2* gradient echo sequence, which is extremely sensitive to compounds with magnetic characteristics. The phase and magnitude of SWI can aid in the diagnosis of a variety of diseases. Spatial differences in the primary magnetic field of the magnetic resonance imaging (MRI) scanner have a significant impact on phase data. When acquiring SWI in diagnostic imaging, the axial acquisition is the most common plane of alignment. Because of the relative heterogeneity in patient placement and anatomy, clinical requirements frequently lead to changes in alignment angles. The line of the anterior and posterior commissure AC-PC can change in direction regarding the transverse plane of the MRI system for many patients receiving brain MRI. We studied whether there are any major effects on SWI phase data due to oblique orientation. According to the resulting data, there were considerable changes in phase values between axial and anatomically aligned cases.