A novel type of drug-delivery scaffold based on bioactive glass (BG) and of Chitosan (CH) loaded with Streptomycin Sulfate (STRS) were prepared by improved freeze-drying. we synthesized a BG using the sol-gel method, mixed with a constant ratio of CH (BG:CH = 1:1 wt %). So, we have two samples: CH/BG (0% STRS) and STRS-loaded CH/BG (20% STRS) scaffold. The development of new composite scaffolds based on the combination of (CH) with (BG) scaffolds as a carrier to an antibiotic drug (STRS) for the application in bone tissue engineering. In this work, CH/BG and STRS-loaded CH/BG scaffolds. The obtained materials were characterized by different techniques X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR), Field Emission Gun Scanning Electron Microscopy (FEG-SEM), and Energy Dispersive X-ray Analysis (EDXA) before and after soaking in (SBF). Bioactivity results of the prepared scaffolds showed exhibits a deposition of a layer of Calcium Phosphate on their surfaces. The results showed that the scaffolds had high porosity with open pores. Furthermore, the BG particles were homogenously distributed within the scaffolds. According to the obtained results, STRS-loaded CH/BG (20% STRS) sample has higher bioactivity than CH/BG (0% STRS) sample.