In this study, polysaccharide polymers /Hydroxyapatite composite scaffolds were prepared by using freeze-drier processing technique. The microstructure and morphology as well as mechanical strength of the scaffolds were characterized by XRD, FTIR, SEM, EDX, and other methods. The porosity ratio and in vitro biomineralization of the scaffold were also evaluated. It was found that, both porosity and compressive strength are strongly dependent on the concentration of HA. The porosity was reduced from ≈ 87 ±5.1% to 66.7±3.2%, while the mechanical measurements revealed that, the compressive strength reaches the highest value 23.96±0.82 MPa by adding HA to hybrid polymers. In addition, Blended hydroxyethylcellulose to sodium alginate cause increase of total pore volume inside scaffold, decrease in mechanical properties and the presence of bioceramic inside scaffolds structure enhances the precipitation and biomineralization of HA from SBF on scaffolds surface. Thus results suggest that these biocompatible composite scaffolds can be useful for bone tissue regeneration.