This work was designed to determine the quality and safety of blood cockle (Tegillarca granosa) meat. Cockle samples (length and weight 3- 9cm and 25- 37g, respectively) were obtained from El-Madia beach, Alexandria during February and March 2022. The values of the cockle flesh's moisture (81.13%), crude protein (12.39%), fat (1.22%), ash (1.05%) and carbohydrates content (4.21%ww) were determined. The most abundant EAAs were leucine (6.67), phenylalanine+ tyrosine (5.84) and methionine (1.64) g/100g protein. Total SFAs, MUFAs, and PUFAs recorded 52.61%, 21.81%, and 25.5%, respectively. Lipid health indices; ∑ω-3/ω-6, IA, IT and h/H recorded 4.97%, 1.48, 0.58 and 1.09, respectively. Macro minerals; Na, K and Ca recorded 3735.1, 1859.8 and 677.3 ppm, respectively. Chemical pollutants; Pb, Cd, Cr, Co, As and twenty four components of pesticides were detected in flesh samples. However, values of pollutants were under the permissible limits, except for chlorpyrifos (52.8881ppb), recording higher concentration of OCPs than the MPLs (20ppb). In conclusion, based on their values of AAs, FAs, minerals and pollutants, the  cockle samples proved their high quality and safety. Therefore, blood cockle have a good source of nutritive value and safety for human consumption, excluding chlorpyrifos component which should be considered since its value was higher than the permissible level.  .