The present study aimed to improve the health status of Nile tilapia fingerlings fish throughout the early developmental stages and to produce high-quality fingerlings, resist unfavorable environmental conditions. Fry of mixed sex hybrid red tilapia 3 g approximately were obtained from a hatchery (GAFRD) found at km 21, Alexandria. After the acclimatization fish, a total number of 315 fries were stocked in 9 ponds randomly divided into three equal experimental groups, each group containing 105 fries distributed in 3 equal replicate ponds each containing 35 fries. The important results showed that Jojoba oil is superior in its contents of eicosenoic acid (C20:1), lignoceric acid (C24:0), and erucic acid (C22:1). Dietary treatments decreased mortality percentage. It decreased feed intake and improved the feed conversion ratio. It increased values of apparent protein digestibility. Values of hemoglobin, RBC's & WBC's cell count, albumin, creatinine, AST, and ALT were significantly affected. Meanwhile, total protein, globulin, albumin: globulin ratio, uric acid and urea were not significantly affected. Moisture and gross energy of body fish were not affected. Energy retention and protein productive value % improved. From the acquired results, it can be mentioned that under conditions available throughout the carrying of this work, incorporating Jojoba oil in Nile Tilapia rations has a positive growth performance effect and represents the best feed utilization. It has no occurring adverse effects on digestibility or blood content. Also, it can be mentioned that may be occurring an improvement in fish performance related to the complementary impact of fatty acids contents in the two sources of oils that were used in the tested rations compared to the control that contained only sunflower oil. Also, Jojoba oil is considered a growth promoter causing an improvement in their performance and encouraging the improved fish health in their early life to produce good quality fingerlings of fish used later on to produce fish on a large scale.