In the past decade, it has become evident that the entire global climate is warming, a phenomenon that has widespread impacts on biodiversity. Recently, many modeling studies estimated climate-mediated turning in species composition resulted from the integration of local species damage and invasions from other locations. The Suez Gulf is one of the wealthiest fishing regions of the Red Sea in the Egyptian sector. It has unique marine resources rich with natural biodiversity. Recently, it was noted that the Suez Gulf suffers from many pollutants. The various impacts of pollutants on aquatic biodiversity were studied. Observations data associated with the high-quality analysis offered by NASA POWER Project service and climate models outputs were used in describing the regional climate patterns for the historical period and under climate change conditions in both short and “long-term" prediction for the study area. In addition, the climate data were used as input in the derived regression equation to assess its impact on fish abundance. Results indicated that there are small variations between the air and surface temperature compared to the differences between the air and water temperatures during the period 1982–2020, and the change in temperature for air, surface, and water has a similar pattern. Of the eleven fish families showing direct relation between temperature variation and distribution, Carangidae, Scombridae Kawakawa, Clupeidae Sardine, and Mugilidae Mullet were the most prominent. Moreover, there are other controlling parameters affecting the change in the number of fishes in the total catch all over the year and all over the study period other than the temperature itself such as Gulf width, water depth, and fishing activities.