This study investigated the Spatio-temporal variations in the physico-chemical properties of the surface seawater along the northern Red sea. 41 seawater samples were gathered from Ras Gharieb, Hurghada, Safaga, and Qusier cities to measure conservative (temperature, DO, salinity, pH) parameters. In parallel, non-conservative parameters (ammonia, phosphorous, nitrite, nitrate) were analyzed via a colorimetric-spectrophotometer instrument. Our findings revealed that physical parameters fluctuated between 19.01 ± 0.75 - 35.01 ± 0.47 ºC, 5.05 ± 0.54 - 11.70 ± 1.06 mg/l, 39.81 ± 0.35 - 42.31 ± 0.50 ‰, and 8.10 ± 0.14 - 8.50 ± 0.44 for temperature, DO, salinity, and pH, respectively. While chemical parameters ranged from 0.12 ± 0.06 to 1.53 ± 0.20 mg/l for ammonia, BDL to 1.71 ± 0.23 mg/l for phosphorous, BDL to 1.38 ± 0.05 mg/l for nitrite, and 0.09 ± 0.06 to 4.50 ± 1.22 mg/l for nitrate. Statistically, no discernible variation was detected among different seasons for all measurements except temperature, DO, and phosphorous (P < 0.05). In addition, Pearson's correlation analysis showed some positive or negative relationships between temperature and salinity (r = 0.75), salinity and pH (r = 0.50), temperature and phosphate (r = 0.70), salinity and phosphate (r = 0.73), nitrite and nitrate (r = 0.71), temperature and DO (r = - 0.73), DO and phosphate (r = - 0.50), pH and ammonia (r = - 0.71), as well as phosphate and nitrate (r = - 0.55).  These results indicate that physico-chemical properties should be taken into account during the development of management strategies to protect the Egyptian marine environment, especially in the Red sea areas.