Lake Manzala is Egypt's largest lake and one of the most important fishing grounds in the country. Unfortunately, the lake is confronted with numerous environmental challenges that have an impact on water quality. Thus, the purpose of this study was to evaluate some aspects of lake water. Seasonal water samples were collected from three stations in El-Kaboty area in Lake Manzala during the year 2020 (autumn, winter, spring and summer). Water samples were collected and physically and chemically analyzed. The values of temperature (17.5°C in spring -32.6°C in autumn), pH (6.5 – 7.2), EC (1.0-3.8), Iron (0.212-0.072mg L^-1), Manganese (0.017-0.066mg L^-1), Copper (0.005-0.009mg L^-1), Lead (0.005-0.009mg L^-1), Cd (0.003-0.009mg L^-1 ) and Zn (0.018- 0.043mg L^-1 ) were measured. It is noteworthy that the water of Manzala Lake has a percentage of pollution, but it did not exceed the permissible limits of the Egyptian legislation in the national law 48/1982. Reducing the pollution load is recommended to avoid exceeding the permissible percentage that reaches the Mediterranean Sea. The possibility of using isolates to remove iron, manganese, copper, lead, cadmium, and zinc from industrial effluents has been determined. The most effective bioremediation was  Aspergillus niger. Both minerals were bioprocessed at high rates (Fe 48.1%, Mn50.9%, Cu55.5%, Pb63.4%, Cd 95.5%, Zn 36%). The study on the efficacy of Aspergillus niger in reducing heavy metal concentrations is consistent. Thus, it proved its ability to treat other metals with high percentages (Mn100%, Cu88.8%, Pb63.4%, Cd95.5%, Zinc 36%).