Due to their tolerance for high-density aquaculture and relative disease resistance, Tilapia is an important global food source. The economic impact of tilapia on worldwide trade is estimated at $7.5 billion U.S. dollars (USD) annually. Since 2009, tilapia aquaculture has been threatened by mass die-offs in farmed fish in Israel and Ecuador by a novel orthomyxo-like virus called Tilapia Lake Virus (TiLV). Subsequently, the disease was reported in tilapia culture regions worldwide that pose a threat to the global tilapia industry, which not only provides inexpensive dietary protein but also is a major employer in the developing world. Epidemiological surveys indicated that 37% of Egyptian fish farms were affected in 2015 with an average mortality rate of 9.2% and a potential economic impact of around US$ 100 million. Although two published papers claimed that TiLV is present in Egypt, it is worth mentioning that such results have not been confirmed yet. The issue is of interest because tilapia is a popular fish representing many Egyptian exports.