Botanical insecticides are harmless to the environment and living organisms. Searching for novel alternatives for the control of the vector of diseases, Culex pipiens considers an important research point.  Experiments were done in the laboratory to evaluate the larvicidal activity of ethanolic leaf extract of Dracaena arborea. The recorded mortality percentage of the treated larvae was the major indicator to evaluate the efficacy of the Dracaena extract. The median lethal concentrations (LC₅₀) were (139.117and 113.162) ppm at 24, and 48 hours respectively. Facts of histopathological alternations confident the toxicological signs. The most distinctive disorder signs were imagined in the midgut region of treated larvae as the detachment of basement membrane, vacuolization of epithelial cells, and disorder of microvilli.  compared with a normal one. These outcomes conclude the effectiveness of D. arborea ethanolic leaf powder extract as bioinsecticides. Hence, should be incorporated into the integrated pest management strategies as an eco-friendly botanical extract.