The edible mantis shrimp Erugosquilla massavensis is a popular, cheap, and nutritious food source in the Mediterranean coasts. In the present study, sex ratio, morphometric and weight relationships, and the condition factor of the mantis shrimp were studied. Samples were collected from October to December 2021 from the Mediterranean coast of Port Said. In the current study, females (702) dominated over males (610) with the sex ratio in favor of females (1.15:1). Body length-body weight relationship indicated a negative allometric growth pattern for both sexes (b<3). The findings of this study showed well-being and good health condition for both sexes since the condition factor was higher than one (2.576 and 2.424 for males and females, respectively). In addition, the in vitro antiproliferative, antioxidant, and antimicrobial activities of hepatopancreas (HP), muscles (M), and hemolymph (HL) extracts of E. massavensis were evaluated. All extracts exhibited a significant cytotoxic effect on the breast (MCF-7) and liver (HepG2) cancer cell lines, especially at higher concentrations. Significant preference for HP was observed on HepG2 cells, with IC50 dose of 1.14 mg/ml (P < 0.001). However, M extract possessed higher antioxidant properties (49.3%) than HL and HP (37.14% and 26.37%, respectively). Moreover, these extracts showed a high degree of antimicrobial activity, especially against E. coli with an inhibition zone of 38, 31, and 31mm for M, HP, and HL, respectively.