Fish and their products are significant sources of protein, minerals, and omega-3 polyunsaturated fatty acids. However, small amounts of heavy metals in fish tissues can counteract the positive effects of their omega-3 fatty acids, causing considerable damage to organisms. The present study was carried out to assess the pollution caused by the presence of heavy metals (lead and manganese) detected in the Suez province. This purpose was achieved by monitoring their concentrations in surface water at different sites (Attaka Harbor, Oyon Mousa and Kornish) as well as in fish (Siganus rivulatus and Pomadasys stridens). In addition, the relationship between the level of the recorded heavy metals in water and its corresponding residual concentrations in fish tissues was investigated. Tissue samples (liver, gills and musculature) of Sigan, Siganus rivulatus (n=96)andShokhrom, Pomadasys stridens (n=48) were collected from different regions (Attaka harbor, Oyon Mousa, kornish region and local markets) during the four seasons of the year. Results revealed that the periodic difference of lead concentration, based on the obtained data of water samples, showed decreasing levels in the following sequence: spring> winter> autumn> summer, while the concentrations of manganese showed the following results: summer> winter> autumn> spring. Levels of lead in the musculature of both Siganus rivulatus and Pomadasys stridens exceeded the permissible limits proposed by FAO/WHO. Nevertheless,  manganese recorded concentrations were within the limits proposed by FAO/WHO for food standards of fish. Heavy metals concentrations were markedly higher in fish tissues compared to water. Liver and gill tissues showed metal concentrations higher than other tissues. In conclusion, these findings indicate that fish can be used as a biomarker for heavy metal pollution in aquatic ecosystems.