Molluscs, owing to their filtrate ability, can accumulate metals that may contaminate food, causing a negative impact on the health of the consumers. Thus, the main objective of the present study was to investigate the heavy metal concentrations in one of the widest broad and consumed surf clams Mactra olorina available in the Great Bitter Lake, Egypt. The concentrations of the heavy metals (Pb, Cd, Cu, and Zn) were seasonally evaluated in water, sediment, and the soft flesh of M. olorina. The specimens were monthly collected from the Egyptian Great Bitter Lake near Fayed City (Ismailia Governorate) for one year , from April 2009 to March 2010. Results revealed that the annual mean concentrations of heavy metals in water were 1.376±0.562, 0.267±0.329, 2.256±2.909 and 3.355±2.731 μg/l for Pb, Cd, Cu, and Zn, respectively. The corresponding concentration values in the sediment were 0.398±0.355, 0.307±0.244, 1.753±0.464 and 8.643±1.821 for Pb, Cd, Cu, and Zn μg/g, respectively. While, the annual mean concentrations of heavy metals in soft tissues were 0.538±1.130, 0.262±0.283, 5.395±3.115 and 13.043±5.743 for Pb, Cd, Cu, and Zn μg/g, respectively. Interestingly, heavy metals deposited in the tissues of M. olorina, and their environment (water and sediments) recorded a close relationship (0.05 ≥ p ≤0.01) in the current research. In conclusion, though no apparent risk was detected on bivalve consumers from being exposed to a single metal, there is a risk from being exposed to the 4 studied metals combined together, especially for high bivalve-consuming groups such as fishermen. Furthermore, environmental parameters need to consider when to use bivalves as indicators of heavy metal pollution since seasonality could affect the absorption of heavy metals.