The current study was conducted to compare the nutritional values of the wild-captured Pangasianodon hypophthalmus and those of the farm-cultured Pangasius pangasius, pangas. Fish samples were collected from the Meghna River Estuary (from the river and a fish farm) from October 2018 till January 2020 with respect to three seasons. Moisture, protein, lipid, carbohydrate, ash, and fiber contents were estimated. according to AOAC 2000 methods data obtained were analyzed using one- and two-way ANOVA. The means of values were compared using Duncan's test at (p < 0.05). Proximate composition was affected by season and fish environment. Protein content was significantly higher in winter for both wild and farmed fish. Ash, fiber, and carbohydrate contents were higher in winter than in other seasons in both wild and farmed fish. Protein and carbohydrate contents were higher in wild pangas than in farmed fish in all seasons. The ash content of pangas was higher in the wild fish in autumn and winter, while in the farmed fish, the ash content was higher in summer. It was concluded that wild pangas contain higher levels of nutrients than farmed pangas. This variation is due to the feeding regime, feed type, environmental factors, and water depth. However, both wild and farmed pangas are rich in essential nutrients, so both may play a significant role in contributing to the nutritional demands of the population in Bangladesh.