Fish differ in their ability to adapt to the environment and vary in their nutritional and economic values. Therefore, this study was conducted to clarify the dynamics of the biochemical composition of the Tilapia zillii, and detect the impact of salinity, as a limiting environmental factor, on the organism's potential to adapt to the environment. In addition, the assessment of the feasibility of transport and farming operations with their financial returns was also considered. Hence, the green tilapia, Tilapia zillii  that lives in different aquatic environments (fresh: <0.05 ‰  Ismailia Canal - brackish 20:28 ‰  Altemsah Lake - salty 30 - ‰ eastern Altemsah Lake) was subjected to a quantitative/ qualitative study. The approximate composition and biochemical components were seasonally analyzed in the muscle tissue of this species representing different environments. The amount of crude protein, fat, carbohydrates, calorific value, moisture and ash were also measured. The quantitative biochemical analyses showed statistically significant differences (P<0.05) among the samples extracted from the environmental areas of different salinity levels. Similar results were detected in the values ​​of protein, fat, carbohydrates, calories, water, and ash content. On applying the protein electrophoresis technique, the qualitative analysis showed no large qualitative variation among the studied samples.