Eighty-four days feeding trial was conducted to address the growth performance, feeding efficacy rate, body indices, and biochemical parameters of the mono-sex Nile tilapia, when fed different substitution levels of soy and maize with dried taro (Colocasia esculenta) leaves, compared to a control diet. This trial was followed by a 14-days fish digestibility experiment. All treatments were duplicated by using two equal cement basins with 5 equal parts containing 100 fish per each with a recorded initial weight (23.39±0.43g). All growth responses were significantly affected, whether in the four examined fish groups or the control group (P<0.05). Compared to the control, the lowest muscle lipid and the highest muscle protein contents were recorded in fish fed diet 3, (20 % boiled soybean +40% yellow corn). A significant improvement was detected in the plasma total protein and the immunoglobulin  (p < 0.05) of the tilapia fed the four examined diets when compared to the control. Similarly, the highest protein digestibility was recorded for the 4 aforementioned fish groups (p < 0.05). Meanwhile, an insignificant survival rate was observed for both groups; the treated and the control. Furthermore, the liver index and liver composition were significantly affected with regard to the tested fish groups when compared to the control. Results indicated that soy and corn substituted with taro leaves, which contain the important amino and fatty acids required for fish, can significantly promote growth and may provide the market with a low cost-effective and eco-friendly fish diet as well.