The present study was conducted to evaluate the influence of three different levels of yellow corn replacer (dried orange peel) which contained high-quality nutritional compounds for tilapia feeding to enhance fish performance. The inclusion levels of dried orange peel (OP) were 10, 20, and 30 percent besides the control. Fourteen weeks feeding experiment was carried out with mean initial body weight (16.83 ± 0.12 g). The best growth performance parameters, feed utilization, apparent protein digestibility, and blood measurements were recorded for the fish fed moderate level of OP (20%), followed by the third level (30%). To attain the best fish performance and save about 30% of the yellow corn cost, the dried orange peel powder is recommended to be used in tilapia feed.