The current study aimed to investigate the most common pathogenic bacteria that are naturally infecting wild marine fishes collected at different localities along the coastline zone of Hurghada City, Egypt. A total of 300 samples of marbled spine foot Siganus rivulatus and the Haffara Seabream Rhabdosargus haffara were subjected to clinical and bacteriological examinations. The examined fishes showed the characteristic clinical signs and postmortem lesions of vibriosis and photobacteriosis. Based on the morpho-chemical characterization, bacterial isolates retrieved from the naturally infected fishes were identified as Vibrio spp. and Photobacterium spp. Through sequencing 16S rRNA genes, the identities of bacterial isolates were confirmed as V. alginolyticus, V. vulnificus, P. damselae subsp. damselae and P. damselae subsp < em> piscicida. Vibrio alginolyticus was the most frequent isolated bacterial pathogen and represented 54.4% and 46.7% of the total isolates recovered from S. rivulatus and R. haffara, respectively. Thus, the current study confirmed that Vibrio and Photobacterium species remain the most prevalent bacterial pathogens infecting Egyptian Red Sea fishes.  From food safety perspective, these types of infections could pose potential public health hazards.