This study was carried out in three different farms and drainages at EL-Fayoum Government in Egypt.  Five heavy metals (Zn, Cd, Pb, Fe and Cu) were addressed in farms and drain water. The organs (gills, skin, muscles and liver) and blood of selected fish; gathered from various farms and drains, were examined to measure the heavy metals' residue. The results showed that iron was the most accumulated metal in the three drains and farms, while zinc was the most accumulated metal in the Nile tilapia blood. For water treatment, pumpkin showed high removal of Zn (65%) and Pb (50%), while eggplant gave maximum removal values of Fe, Cd and Cu (88%, 78% and 77%, respectively). In the current study, investigation of some biochemical blood parameters was also determined, such as alanine aminotransferase, aspartate aminotransferase enzyme, urea, creatinine, random blood sugar, creatinine kinase, alkaline phosphatase and thyroid-stimulating hormone, thyroxine and triiodothyronine, growth hormone and cortisol hormones.