Fisheries conservation and management studies require a comprehensive description of the general well-being of fish which can initially be obtained through the study of different biological parameters of snow trout, Schizothorax labiatus collected from river Sindh. To evaluate the condition of S. labiatus, the present work was carried out by studying length-weight relationship (LWR), condition factor (K), gonadosomatic index (GSI), and hepatosomatic index (HSI) with respect to sex and seasons. The results of LWR revealed that positive allometric growth was observed in both sexes of S. labiatus in all seasons, except summer and autumn (males) where negative allometric growth was recorded. Significantly (p < /em><0.05) highest K and HSI values for both sexes of S. labiatus were recorded during autumn while the poorest value was noted in the season of spring. On the contrary, significantly (p < /em><0.05) maximum GSI value for both sexes was noted in spring, while the minimum value was recorded during summer. Although, significant (p < /em><0.05) differences in K, GSI, and HSI values were recorded among seasons, yet no significant (p < /em>>0.05) difference was detected between the sexes, except in spring for K and GSI. Hence, it was concluded that seasonality difference in condition indices could be accredited to gonadal changes, feeding intensity, and energy distribution.