This study was planned to determine the quality and aqua veterinary drug residues of some cultured fish and their processed products. Fish samples of the Nile tilapia (Oreochromis niloticus) and mullet (Mugil cephalus) were purchased from a fish farm at El-Fayoum, Egypt during September 2020 and cooked by grilling and frying methods. Quality indices of pH, total volatile nitrogen (TVN), trimethylamine (TMA), thiobarbituric acid (TBA) as well as safety parameters; eight aqua veterinary drugs residues, total plate count (TPC), and spore-forming bacteria (SFB) were determined. Results showed that values of quality parameters were based mainly on fish species and cooking method conditions and they were within the maximum permissible limits (MPLs). With regard to safety, although TPC and SFB were among permitted counts the raw tilapia samples contained 7428ppb tetracycline and 5000ppb aminoglycosides, respectively, however, residues of these compounds were neither detected in grilled or fried tilapia products nor in raw, grilled or fried mullet products as well.  In conclusion, although cultured fish samples are of good quality they are contaminated, especially raw tilapia, by high levels with tetracycline and aminoglycosides residues. It is worthy to mention that, cooking methods could reduce those compounds up to 100%. Hence, in this study, the usage of drugs was recommended to never exceed the MPLs and to ensure withdrawal periods before fish marketing.