Bivalves are important components of the aquatic fauna. Its consumption has been increasing worldwide during the last decades. The study of biochemical composition is much more important from the nutritional point of view. So, this study was conducted to estimate the percentages of edibility, total proteins, total lipids and total carbohydrates of Mactra olorina (Family: Mactridae), Callista florida, Circe rugifera and Gafrarium pectinatum (Family: Veneridae) collected seasonally from the western coasts of the Suez Gulf, Egypt. The results of these parameters showed remarkable seasonal variations for the previous species. For edibility, M. olorina recorded the highest value, while C. rugifera has the lowest value. The highest annual values of total proteins recorded for C. rugifera and C. florida averaged 8.58±2.25 %, 8.19±3.87 %, respectively. While total lipids recorded a high annual value averaged 5.38±3.49% for C. florida and the minimum annual average of 1.90±1.64% for M. olorina. Furthermore, the highest annual value of total carbohydrates was 23.46±11.98% for C. florida, while the lowest value recorded in G. pectinatum (9.16±10.38%). However, this study concluded that M. olorina and C. rugifera consider as a good animal protein sources with high edibility percentage and lower lipid content for human consumption.