Schistosomiasis has been classified as a category II disease after malaria in importance as a targeted tropical disease. Praziquantel (PZQ) which is the chemotherapeutic agent of choice against adult worms, already faces drawback of drug resistance in some Schistosoma isolates. Therefore, searching for new alternative drugs has been the intention of many researchers. In the current study, the effect of different doses 6.25, 12.5, 25. 50. 100 and 200 mg/ml of Origanum majorana,Ziziphus spina-christi, and Salvia fruticosa extracts on the snails Bulinus truncatus of the S. haematobium and Biomphalaria alexandrina of the Schistosoma mansoni as well as on the free-living stages miracidia, in addition, the cercariae for both Egyptian species of schistosomes were studied. The results declared that Origanum majorana,Ziziphus spina-christi showed efficacy against snails (molluscicidal), miracidia (miracicidal), and cercariae (cercaricidal) for both Egyptian species of schistosomes in the in vitro, while Salvia fruticosa was less effective than the previous ones